ROLE OF FETUIN-A IN ANGIOPATHY IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

Abstract

Background: Fetuin-A is a negative acute phase protein known to inhibit insulin signaling and pathologic calcification, has emerged as a promising candidate biomarker for diabetes risk.
Aim of work: Evaluate the role of fetuin-A in type 2 diabetes patients &its relation to angiopathy.
Subjects & Method: Serum Fetuin-A levels, were assessed in 52 patients with T2DM and 30 normal glucose tolerance (NGT) using enzyme linked immunosorbont assay (Elisa).
Results: T2DM subjects had significantly higher Fetuin-A levels than NGT subjects (420.7± 115.8 mg/l vs 215.6± 19.7 mg/l, P< 0.001).In the Pearson’s correlation coefficients, Fetuin-A levels and clinical parameters: Fetuin-A was positively correlated with HOMA-insulin resistance index (HOMA-IR),), HbA1c, triglyceride (TG), Low density lipoprotein cholesterol (LDL-C) , fasting plasma glucose (FBG) and 2 h post-prandial blood glucose (2 h pp) (P < 0.001), but negatively with High-density lipoprotein cholesterol (HDL-c).
Conclusions:Our study suggests that the serum Fetuin-A levels may be associated with macro angiopathies in T2DM patients. Therefore, detecting early serum Fetuin-A levels inT2DM provides an opportunity to intervene of Atherosclerosis in diabetic patients and giving timely treatment for the prevent of diabetic vascular complications.
Keywords: type 2 diabetes mellitus, Fetuin-A, Atherosclerosis.